ELI5: Explain Like I'm 5

Biosafety level

Okay kiddo, so you know how there are some things that can make you sick or hurt you? Well, scientists and doctors sometimes need to work with those things to study them and find ways to help people. But they also need to make sure they don't get sick themselves or spread those things to other people or animals. That's where biosafety levels come in.

Biosafety levels, or BSL for short, are levels of safety that scientists and doctors use when they work with dangerous things like germs or chemicals. There are four levels, from lowest to highest: BSL-1, BSL-2, BSL-3, and BSL-4. The higher the level, the more dangerous the stuff they're working with is.

Let's start with BSL-1. This is the lowest level, and it's used for things that aren't very dangerous. Scientists and doctors who work with BSL-1 stuff usually wear a lab coat, gloves, and goggles to protect themselves, but they don't need to wear special suits or work in special rooms. BSL-1 stuff might include things like harmless bacteria or viruses that don't make people very sick.

Next up is BSL-2. This level is used for things that can make people sick, but there are treatments and vaccines available to help if someone gets infected. Scientists and doctors who work with BSL-2 stuff might wear stronger gloves and goggles, and they might work in a special room with a door that closes automatically. They might also need to disinfect their lab equipment and clothes before they leave the lab. BSL-2 stuff might include things like the flu virus or bacteria that can cause food poisoning.

BSL-3 is the next level up. This level is used for things that can make people very sick, and there might not be any treatments or vaccines available. Scientists and doctors who work with BSL-3 stuff wear special suits that cover their whole body, including their face and hands. They might work in a room with negative air pressure, which means that air from the room doesn't escape to other parts of the building. They might also need to take a shower and change clothes before they leave the lab. BSL-3 stuff might include things like tuberculosis or the Ebola virus.

Finally, there's BSL-4. This is the highest level, and it's used for things that are extremely dangerous and often deadly. Scientists and doctors who work with BSL-4 stuff wear special suits that look like spacesuits. They might work in a room that's completely sealed off from the outside world, with its own air supply and decontamination systems. They might also need to be monitored for any signs of infection or illness for weeks or even months after they leave the lab. BSL-4 stuff might include things like the smallpox virus or deadly strains of Ebola.

So, biosafety levels are like different levels of protection that scientists and doctors use when they work with things that can make people sick. They start at BSL-1, which is the lowest level and used for things that aren't very dangerous, and go all the way up to BSL-4, which is the highest level and used for things that are extremely dangerous and often deadly. Each level has its own rules and precautions to keep everyone safe.