The center-of-mass frame is like a special view where objects look like they aren't moving at all. Imagine you're sitting in a car and someone throws a ball towards you. From your point of view, the ball is moving towards you. But if you were to get out of the car and run alongside it at the exact same speed as the car, the ball would look like it's just floating in the air, not moving towards you at all.
This is similar to what happens in the center-of-mass frame. If you have two objects moving towards each other, like two cars crashing into each other, there's a special point between the two called the center of mass. Imagine it like a big, imaginary marble that's exactly in the middle of the two cars. When you watch the crash happen from the center-of-mass frame, it looks like the cars are both coming towards the center of mass and then just stopping there, with no movement afterwards. This is because the two cars are moving equally towards the center of mass, cancelling out each other's movements.
The center-of-mass frame is really useful for scientists and engineers because it shows the most accurate picture of what's going on in a system when objects are moving. By looking at the situation from the center-of-mass frame, we can better understand the forces involved and make better predictions about what will happen next.