Combined drug intoxication is when someone who takes two or more drugs at the same time and these drugs can work together to make the person very sick or even die. Imagine if you were playing with different toys and you mixed them together, they might not work well together and cause a big mess. The same thing can happen with drugs, if you mix different drugs together they might not work well together in your body and cause problems. Sometimes, people might take different drugs thinking they will feel better or get high but mixing them can make things worse. It is really important to only take medicine that a doctor tells you to take and to never mix drugs without talking to a doctor first.