Cryptogenic disease is a health problem that happens when doctors can’t figure out what is causing it. They can’t tell why the person is feeling sick or having the symptoms they have. Doctors look at all the tests they can do and try to find the cause but they can’t. It is like when we are playing hide and seek and we spend lots of time looking everywhere, but we can’t find the person who’s hiding. That’s why it is called cryptogenic, because it is like something that was hidden or a mystery.