ELI5: Explain Like I'm 5

Diffusion limited enzyme

Okay kiddo, imagine you have a big candy jar and you want to eat all the candies in it. But there's a small opening at the top of the jar that only lets a few candies out at a time. This makes it hard for you to eat all the candies quickly, doesn't it?

Well, this is kind of like enzymes in our bodies that break down or use up certain things in our cells. Enzymes are like little workers that help reactions happen faster, but they can only work so fast because there's only so much room around them for the things they need to use.

Sometimes, the molecules that the enzyme needs to work on are really big or there are a lot of them around, and it becomes really hard for the enzyme to get to all of them. This is what we call a diffusion limited enzyme.

It's like if you had a hundred friends all trying to fit into your house at the same time through one tiny door - it would be really hard for them to all get inside, right? That's what it's like for the enzyme when there are too many of the molecules it needs around.

So, even if the enzyme is working as fast as it can, it still won't be able to keep up with all the molecules because there are simply too many of them around. Does that make sense?