ELI5: Explain Like I'm 5

Epistasis

Epistasis is like a game of dominoes, where each piece affects the next one. Think of it like building a tower with blocks. The way you stack the blocks will affect how high the tower can go.

In genetics, epistasis is when one gene affects how another gene works. It's like one gene is the domino that needs to be pushed in order for the rest to fall in line. These genes work together to determine traits, like hair color, eye color, or height.

For example, if you have a gene for brown eyes and a gene for blue eyes, the brown eye gene might be the domino that needs to be pushed in order for the blue eye gene to be expressed. So, even though you have a gene for blue eyes, if the brown eye gene is dominant, then you will have brown eyes instead.

Overall, epistasis helps to explain how different genes work together to determine our traits, and why we all look different from each other.