ELI5: Explain Like I'm 5

History of research on Caenorhabditis elegans

Caenorhabditis elegans is a tiny, transparent worm that scientists have studied for more than 50 years to understand how living things work.

Beginning in the 1960s, scientists began using C. elegans to study how genes work because it has a small, simple genome. This means that scientists can study the effects of specific genes easily in this worm.

In the 1970s, Sydney Brenner and his team spent years studying the development of C. elegans, trying to figure out how its cells divide into different types and how it forms different parts of its body. Their work led to important discoveries about how living things develop.

In the 1990s, John Sulston and his team sequenced the entire genome of C. elegans, which means that they figured out the order of each gene in its DNA. This was an important milestone because it allowed scientists to study the worm’s genes in greater detail.

Since then, scientists have continued to use C. elegans to study many different topics, including aging, neuroscience, and disease. They have also used it as a model organism to study how organisms survive in extreme environments.

In summary, scientists have been studying C. elegans for more than 50 years to learn how genes work, how living things develop, and how organisms survive in different environments. Its small, simple genome has made it an ideal organism for genetic research.