ELI5: Explain Like I'm 5

Mutation bias

Okay kiddo, so you know how all living things have DNA inside their cells that makes them who they are? Sometimes, changes happen in that DNA and those changes are called mutations.

Mutation bias is when some types of mutations happen more often than others. For example, say you were trying to make a cake and you accidentally put in too much sugar. That's a mutation in the cake recipe! But if you always make that same mistake every time you bake a cake, then you have a mutation bias towards adding too much sugar.

In DNA, mutation bias can happen because of different reasons. Sometimes it's because certain parts of DNA are more likely to change than others, kind of like how some areas of your room might get messier faster than others. Other times, it's because of something called natural selection, which means certain mutations are better for survival and get passed down more often.

Overall, mutation bias helps scientists understand how and why certain mutations happen more often, which can be really helpful in studying how traits are inherited and how diseases develop. Does that make sense, kiddo?