Nucleic acids are tiny bits of material that your body uses to build instructions for how to make all the different parts of your body. Think of nucleic acids like building blocks for your cells. They are made up of four different substances called "letters" - A, C, G, and T. Just like how you can build different things with different shaped blocks, scientists can build different "messages" or instructions by arranging these four letters in different patterns.
Nucleic acid design means that scientists are using their knowledge of how these building blocks work to create new messages, or instructions, that can be used to help people. They start by thinking about what they want to create - maybe a cure for a disease or a new material for building. Then, they use computer programs and other tools to create a string of letters, called a "sequence," that will tell the cells in our bodies how to create that new thing.
Once they have created the sequence, scientists can use special machines to create the actual nucleic acid molecule. They can then test these molecules in the lab to see if they work the way they wanted them to. This process takes a lot of time and effort, but it can lead to amazing discoveries that can improve the lives of people all over the world.