ELI5: Explain Like I'm 5

Phylogenetic footprinting

Phylogenetic footprinting is like a game of spot the difference, but for scientists. They look at the DNA sequences of different organisms, like humans, mice, and even bacteria, and try to find parts that are the same.

These parts are called conserved regions and they are really important because they usually contain instructions for making something essential.

For example, let's say you are trying to figure out how to make a big castle out of Legos. If you have a set of instructions that are the same as another person's set of instructions, then you know those steps to build the castle are really important.

Scientists use these conserved regions to figure out what parts of the DNA are important for making proteins, which are the building blocks of cells. They can also figure out which genes are related to certain diseases or traits by looking at what genes are conserved across different organisms.

It's like a giant puzzle, but instead of putting together pieces, scientists are trying to understand how different organisms have evolved and how they're related to one another.