ELI5: Explain Like I'm 5

Protein I-sites

Protein i-sites are like little pockets inside a larger protein. Imagine you have a big toy box filled with stuffed animals. Each stuffed animal is like a protein, and inside each stuffed animal there is a secret pocket – that’s the i-site!

These little pockets are very important because they can do special things. Some i-sites can help the protein stick to other things, like a magnet sticking to a refrigerator. Other i-sites can help the protein change its shape, like a transformer toy that can change from a car to a robot.

Scientists study these i-sites because they can tell us a lot about how the protein works. Just like how you learn about the toys you have by playing with them, scientists learn about proteins by studying their i-sites. By understanding i-sites, scientists can figure out new ways to use proteins to help people – like creating new medicines or making better fuels for cars.