Okay, so imagine you have two pieces of metal that are really, really good at conducting electricity. We call these pieces "superconductors" because they don't have any resistance, which means electricity can flow through them without losing any energy.
Now let's say you put a piece of material in between these two superconductors that is NOT good at conducting electricity. We call this material an "insulator" because it doesn't let electricity flow through it easily.
So what happens when you have a setup like this? Well, if you cool the whole thing down to a really, really cold temperature (like near absolute zero), something really cool happens. The electrons in the superconductors start to act really weird and move in what we call "Cooper pairs" - basically two electrons that stick together and move as one unit.
And because of how the insulator between the superconductors interacts with these Cooper pairs, the electricity can actually flow through it too! This creates what we call a "superconductor-insulator-superconductor" setup, or SIS for short.
So why is this important? Well, SIS setups can be used in things like very sensitive detectors for things like radio waves and cosmic rays. They can also be used for making really powerful magnets, like the ones used in MRI machines to look inside our bodies. Pretty cool, huh?