Okay kiddo, two-hybrid screening is like a puzzle game for scientists. Let's say we have two things we want to see if they can connect or talk to each other, like two magnets. But we can't just look at them and see if they stick together, we need a special science game to help us figure it out.
So what scientists do is they take one thing and give it a special name tag, like a blue tag. They take the other thing and give it a different tag, like a red tag. Then they put them in a big bag and shake it up.
The next step is where the science game gets really cool. Scientists put these things into cells that are missing a special 'part'. Let's say it's like trying to replace a missing key in your toy car. The cells can't work properly without this special part, so they need the blue and red things to come together and fix it!
Now, if the blue thing and red thing can connect and fix the missing part, the cell will start working again! Scientists can then look at the cell and see that the blue and red things connected together to fix the missing part. This means that they are friends and like talking to each other!
So that's why it's called two-hybrid screening. Scientists are finding out if two things are friends and like to 'hybrid' together in the cell. It's like a special puzzle game that helps scientists figure out how things work in the body. Cool, right?