ELI5: Explain Like I'm 5

X-inactivation

Okay kiddo, I'll explain x-inactivation as simply as possible.

You know how we humans have two X chromosomes (one from our mom and one from our dad) and males only have one X chromosome and one Y chromosome? Well, every cell in our body needs to shut down one of the X chromosomes so we don't get too much of the proteins that X chromosomes code for. X-inactivation is the process of turning off one of the X chromosomes in each and every cell in female mammals. It's like we have two TVs playing the same show and we need to mute one of them so we only hear it once.

This process happens randomly in each cell during embryonic development, and once that X chromosome is turned off, it stays off in all the cells that come from that original cell. So some of our cells will have mom's X turned off, while other cells will have dad's X turned off. But don't worry, our bodies are smart enough to make sure that each of our cells has the same X chromosome turned off.

X-inactivation is very important because it helps to balance out the amount of proteins made by the X chromosome in males and females. Without x-inactivation, females would make twice as many proteins from their two X chromosomes compared to males with their one X chromosome, which could cause some problems.

So that's x-inactivation in a nutshell, pretty cool, huh?