ELI5: Explain Like I'm 5

Barr body

Okay kiddo, let me explain to you what a barr body is. When a baby is growing in its mother's womb, it has two X chromosomes - one from its mom and one from its dad. But when the baby becomes a girl, one of those X chromosomes gets turned off so that the girl's cells only use one of them. This turned-off X chromosome is called a barr body. It's like having two sets of Legos to play with, but you only get to use one set at a time.

The reason the body does this is because it would be too much genetic material for the cells to use both X chromosomes all the time. So, the body chooses which one to turn off randomly in different cells throughout the body. This process is called X-inactivation.

But don't worry, the barr body doesn't harm the girl's body. It just sits there in the cell, all coiled up and compact, not doing anything. So, that's what a barr body is - an inactive X chromosome in a girl's cells that isn't harmful but just helps the cells function better.
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