ELI5: Explain Like I'm 5

Cell migration

Okay kiddo, imagine you are a little bug living in a house made up of lots of little parts called cells. Your house has different rooms and hallways that you need to move around in to get from place to place, just like cells in our body need to move around to do important jobs like healing wounds or fighting germs.

Sometimes, your bug friends need to move to different parts of the house too. They might need to meet up with other bugs to work on a project or escape from a predator that's trying to eat them. When they need to move, they use their little legs to crawl through the hallways and doors to get where they need to go.

Cells do something similar, but instead of legs, they use tiny finger-like structures called filopodia to probe and feel their way around. They also use special molecules called adhesion proteins to stick to other cells and surfaces in the body. This is especially important when cells need to crawl through tight spaces like blood vessels or connective tissue.

But unlike bugs, cells can also change their shape to move in new directions. They can stretch their arms out like a jumping jack or squish their body down to wiggle through a narrow passage. Sometimes, they even use special motor proteins that move along tiny tracks inside the cell to pull themselves forward.

Now, this all sounds like a lot of work, right? And it is! That's why cells need a lot of energy to move around. They get this energy from a molecule called ATP, which is like a little battery that powers all the cell's activities.

So, in summary, cell migration is when cells move through the body to do important jobs like fighting germs or healing wounds. They use finger-like structures and special adhesion proteins to stick to surfaces, as well as their ability to change shape and use energy to power their movements. Sometimes, they even use tiny motor proteins to pull themselves forward. Just like bugs in a house, cells need to move around to get things done!