ELI5: Explain Like I'm 5

Cholinergic anti-inflammatory pathway

So, you know when you get a boo-boo and your body can get really mad and inflamed? Well, your body has a special way to calm down that inflammation called the cholinergic anti-inflammatory pathway.

Here's how it works:

1. Your body has a nerve called the vagus nerve that sends messages to different parts of your body.
2. When you get an injury or infection, your immune system goes into action to fight it. This can cause inflammation, which is like a signal to your body to send help.
3. The vagus nerve sends a message to your immune system to stop the inflammation, kind of like a parent telling their kids to calm down.
4. This message causes the release of a chemical called acetylcholine, which tells your immune system to calm down and stop making so much inflammation.
5. Once the inflammation goes down, your body can focus on healing the injury or fighting the infection.

So, the cholinergic anti-inflammatory pathway is like a special way your body can calm down inflammation when it's not needed anymore.