ELI5: Explain Like I'm 5

Histamine

Histamine is a chemical that your body makes. It is made in certain cells in different parts of your body and it helps your body respond to things like infections or allergens. It can cause some reactions in your body like itchiness, sneezing, or coughing. When someone has allergies, the body may make too much histamine and this causes the symptoms of allergies.