ELI5: Explain Like I'm 5

Isothermal microcalorimetry

Well kiddo, do you know what a thermometer is? It helps us measure the temperature of things, right? Now, imagine having a special thermometer that can measure how much heat is produced or released when something happens. That's called a microcalorimeter!

Isothermal microcalorimetry is a type of microcalorimetry that keeps the temperature of a sample constant while measuring the heat exchanged between the sample and the surroundings. Basically, it tells us how much heat is involved in a chemical reaction or a biological process that's happening in a sample.

How does it work? Imagine you have a cup of hot cocoa that you want to measure with a microcalorimeter. You put the cup inside a chamber that's at a constant temperature, let's say 25 degrees Celsius. The chamber is insulated so that no heat goes in or out from there. Then, you start measuring the temperature of the cocoa every few seconds or minutes.

As the cocoa cools down, it releases heat to the surroundings, which the microcalorimeter can detect. At the same time, the microcalorimeter can tell how much heat is produced by the bacteria or yeast that might be in the cocoa, if any. This helps scientists study the metabolism of microorganisms or the activity of enzymes in a sample.

Isothermal microcalorimetry can be used in many fields, such as microbiology, food science, pharmacology, and nanotechnology. It's a powerful tool for understanding how things work at the microscopic level and could help us develop new drugs, food products, or materials in the future. Neat, huh?