Okay kiddo, imagine you're playing catch with a friend. You throw the ball to your friend and they catch it. You do this a few times and notice that your friend is pretty good at catching the ball. You might say that your friend's "mean response" to catching the ball is pretty high.
Now let's say you want to throw the ball to your friend but they're not around. You want to know how likely it is that they'll catch the ball if they were there to catch it. You can use the information you gathered from playing catch with them before to make a guess. This guess is called a "predicted response".
So basically, mean response is the typical or average response someone or something does. And predicted response is a guess of what someone or something might do based on past experiences. It's like trying to predict the future based on what happened in the past.