ELI5: Explain Like I'm 5

Mitochondrial DNA

Mitochondrial DNA (mtDNA) is a special kind of DNA that is found in tiny structures inside our cells called mitochondria.

Imagine that our body is like a big city and the mitochondria are like little power plants that provide energy to the buildings. Just like how power plants have their own blueprint or instructions on how to generate electricity, our mitochondria have their own little set of genetic instructions that help them create the energy we need to live.

Unlike the DNA that you hear about in biology class, which you get half from your mom and half from your dad, mtDNA is only inherited from your mother. This means that if you are a girl, you have the same mtDNA as your mom, and if you are a boy, you get your mtDNA only from your mom.

Because of this unique inheritance pattern, mtDNA can be traced back through your maternal line for many generations. Scientists use this information to study how humans migrated around the world and who our ancestors were.

While the DNA in our cells' nuclei is constantly shuffling and changing, mtDNA remains relatively stable within our own lifetime. However, mutations can still occur over time, and when they do, they can cause problems with energy production in the mitochondria. These problems can lead to diseases that affect the body's ability to function properly, such as mitochondrial myopathies.

In summary, mitochondrial DNA is a special type of genetic instructions found in tiny power plants inside our cells. It's only inherited from our mothers and can be used to trace our maternal lineage and study human history.