ELI5: Explain Like I'm 5

Prime editing

Okay kiddo, let's talk about prime editing!

You know how sometimes when you draw a picture, you make a mistake and need to erase it and start over? Scientists who study genes and DNA also want to fix mistakes, but they use something called prime editing instead of an eraser.

Every living thing, including you and me, has instructions for how our bodies should work inside of something called DNA. Think of it like a recipe book for your body. Sometimes, there are spelling mistakes or typos in these instructions, and that's where prime editing comes in.

Prime editing works by using a special tool called an enzyme. This enzyme travels to the part of the DNA that has the mistake and "cuts" the DNA strand. But, instead of just "erasing" the mistake, the enzyme also brings in a new piece of DNA to fix the problem. It's kind of like using a puzzle piece to replace a missing piece in a picture.

Scientists can use prime editing to fix or even add new instructions to DNA. This is really helpful when trying to cure diseases, like cancer or genetic disorders. Think of it like giving your body a new recipe to follow so it can work better.

Prime editing is still a new and complicated thing, but it's really exciting because it could help us create new treatments and cures for all kinds of things.