ELI5: Explain Like I'm 5

Protein superfamily

Okay kiddo, imagine a big family with lots of different members. Some members have something in common, like the same last name or the same hair color. Well, proteins are like that too! There are lots of different proteins in the world, but some of them have things in common and belong to the same family, just like some people in a family have things in common.

Now, imagine if there were lots and lots of protein families, just like there are lots and lots of families in the world. But what if some of those families were related to each other? Kind of like how your mom might have a cousin who is related to your dad's family. That's kind of what a protein superfamily is!

A protein superfamily is a really big group of protein families that are kind of like distant cousins. They all have something in common, like a certain shape or function, but they're not all exactly the same. Just like how your mom's cousin might look a little different from your dad's relatives.

Scientists use protein superfamilies to help them understand more about proteins and how they work. They can study the similarities and differences between different protein families in a superfamily to figure out how they evolved and what they do in the body. It's kind of like a big puzzle, but with proteins instead of puzzle pieces!