ELI5: Explain Like I'm 5

Adaptive clinical trial

An adaptive clinical trial is like playing a game where you have to figure out the rules as you go along. In a regular game, you might play through the whole game using the same set of rules, but in an adaptive game, the rules might change based on how well you're doing.

Similarly, in a regular clinical trial, everyone who is taking part gets the same treatment or medicine. But in an adaptive clinical trial, the people in charge might change things partway through based on how well the treatment is working. For example, they might switch some people to a different medicine, or they might adjust the dosage of the current medicine.

Adaptive clinical trials are like this because they are trying to find the best way to treat people with a certain disease, and sometimes it takes trying different things before you find what works best. It's like when you're trying to build a tower out of blocks, sometimes you have to try a few different shapes before you find the one that works best.

Adaptive clinical trials can sometimes be better than regular clinical trials, because they can get results faster and with fewer people. But they can also be more complicated, because the people in charge have to keep track of all the changes they make and how they affect the results.