The Pleistocene Extinctions are a time in history when most of the large animals that lived on Earth, like mammoths and saber-toothed tigers, suddenly died off. Nobody knows exactly why this happened, but scientists think that a combination of climate change, human hunting, and diseases like the plague all played a part in the extinction of so many animals. One thing is for sure though - the Pleistocene Extinctions were a turning point in Earth's history, and changed the way that humans and many other animals lived their lives forever.