Okay kiddo, have you ever eaten something that made you feel sick, like your tummy hurt or you had a rash on your skin? That's what we call an adverse reaction. It means that your body didn't like something you ate or touched.
Sometimes, people may have adverse reactions to things like medicine or vaccines they get from the doctor. This means that their body may not react well to the medicine and they could get sick or have a bad reaction.
It's important to let grown-ups know if you ever have an adverse reaction to something, so they can help you feel better and find out what caused it. And remember, just because something doesn't work well for you, doesn't mean it won't work well for someone else. We're all different and our bodies react differently to things.