Okay kiddo, Louisiana is a state in the United States and it has many different areas or "districts" within it. One of these districts is called the "District of Louisiana".
This district is actually part of the federal court system and it covers a lot of land in Louisiana, including some big cities like New Orleans and Baton Rouge.
The District of Louisiana has its own judge who makes decisions about cases that come up in the district. So, if someone breaks a law or gets into trouble in this part of Louisiana, they might end up in court in the District of Louisiana.
Overall, you can think of the District of Louisiana as a special place where legal matters are handled in a specific part of Louisiana.