ELI5: Explain Like I'm 5

Transcriptome

Your body is made up of many tiny building blocks called cells. Each cell has a blueprint or recipe book called a genome that tells it how to carry out its specific function. The genome is made up of DNA which contains instructions that guide our development and growth, and determine our genetic traits.

In order for a cell to do its job properly, it needs to know which parts of the recipe book to read or access. Think of it like a chef looking at a cookbook and selecting the recipe they need to cook a certain dish. The process of selecting and reading certain parts of the recipe book is called the transcriptome.

The transcriptome is made up of all the molecules, called transcripts, that are produced when parts of the genome are read or expressed. These transcripts are made up of RNA molecules and are like messengers that take the message from the recipe book and deliver it to different parts of the cell where it is needed.

Just as different recipes require different ingredients and instructions, different cells in our body also require different transcripts to carry out their specific functions. For example, a skin cell needs different transcripts than a muscle cell. The transcriptome helps cells to carry out their specific functions by allowing them to access the right parts of the recipe book.

Scientists study the transcriptome to better understand how cells work and to develop treatments for diseases. By understanding which parts of the recipe book are being read or expressed in different cells, scientists can identify new pathways to target for drug development and therapies.

So, the transcriptome is like the messenger that helps cells to read and access the right parts of the recipe book or genome, and it is an important tool for scientists to better understand how cells work and develop new treatments for diseases.