ELI5: Explain Like I'm 5

Transmembrane potential difference

Okay kiddo, let's talk about something called transmembrane potential difference. Cells are the building blocks of all living things, and just like every building block they have walls called membranes that keep things in or out. The membranes are like tiny gates. Some things can go in and out easily, while other things can't.

Now, inside these cells there are tiny machines called ions. They have electric charges, just like the positive and negative ends of a battery. These ions move in and out of the cell through the gates in the membrane.

Transmembrane potential difference is the difference between these ion charges on the inside and outside of the membrane. Imagine it like one side of the gate has a lot of positive ions, and the other side has a lot of negative ions. This creates an electric charge, kind of like a tiny battery, and that's what we call transmembrane potential difference.

This transmembrane potential difference is important for many things, like allowing nerve cells to send electrical signals in our body, and helping our muscles contract when we move. So, it's like a tiny electric current that helps our body work!