The Binding of Isaac is a game where you play as a little boy named Isaac who is being punished by his religious mother for being sinful. He tries to escape into the basement of his house, where he faces a lot of scary monsters and challenges.
The game is called Binding of Isaac because Isaac's mother is trying to sacrifice him to God, just like in the Bible story where Abraham was going to sacrifice his son Isaac. But in the game, Isaac fights back against his mother and the monsters in the basement to try and survive.
The mechanics of the game involve exploring the basement and fighting monsters with different items and power-ups that you can find along the way. Each time you play, the game is randomized, meaning that the layout of the levels and the items you find will be different.
The goal of the game is to defeat all the bosses and unlock new items to make yourself stronger. The game is challenging and can be quite difficult, but it's also a lot of fun and has a lot of replay value.